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What is Ewings sarcoma?

     Ewing's sarcoma is a malignant (cancerous) bone tumor which affects children.  Ewing 's sarcoma can occur any time during childhood, but usually develops during puberty, when bones are growing rapidly.  The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Children may also break a bone at the site of the tumor after a seemingly minor trauma (pathologic fracture). Fever may also be present.
- Ewing sarcoma family tumors are the second most common type of bone cancer in children and adolescence.
- Approximately 200 new cases of this type of tumor are diagnosed in
the United States per year.
- Almost 50 percent of patients with Ewing family of tumors are
between 10 and 20 years of age.
Treatment Strategies
     From past experience, it is clear that most patients who are treated with local therapy alone (surgery and/or radiation therapy), will have tumor recurrence, usually at a distant site. For this reason, chemotherapy has become part of the standard treatment for Ewing family of tumors. Chemotherapy kills tumor cells at the site of primary disease as well as tumor cells in other areas of the body that cannot be seen. Vincristine, cyclophosphamide, doxorubicin, etoposide and ifosfamide are the most commonly used chemotherapeutic agents.

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